tag:blogger.com,1999:blog-9174025374821038087.post6026399825374680951..comments2024-01-29T17:51:55.608+00:00Comments on Nige's Diet & Nutrition Blog: EnzymesNigel Kinbrumhttp://www.blogger.com/profile/03368973941328529619noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-9174025374821038087.post-33939820781812550592010-01-20T12:20:51.229+00:002010-01-20T12:20:51.229+00:00I have left a comment on Back to That Calorie Thin...I have left a comment on <a href="http://drjamescarlson.blogspot.com/2010/01/back-to-that-calorie-thing.html" rel="nofollow"><b>Back to That Calorie Thing.....?</b></a>Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-54847260588366035332010-01-20T11:57:06.222+00:002010-01-20T11:57:06.222+00:00Nige, how about discussing your theory with James ...Nige, how about discussing your theory with James Carlson? He did biochemistry.xhttps://www.blogger.com/profile/14809802792206636250noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-76217883791750019542010-01-19T22:59:51.201+00:002010-01-19T22:59:51.201+00:00That was the original plan. However, when I admitt...That <b>was</b> the original plan. However, when I admitted that I hadn't read GCBC, Gary advised me to read it before disagreeing with any of it.<br /><br />Having read the notes to GCBC, I don't think that there's much point in me buying the book for the sake of the 1% of it that I disagree with. I therefore don't think that there's going to be a phone discussion now.<br /><br />I much prefer to have discussion here for all to see. It also gives me time to look stuff up!Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-33680528945550992372010-01-19T22:48:49.135+00:002010-01-19T22:48:49.135+00:00Thanks Nige, that makes sense and rings a few memo...Thanks Nige, that makes sense and rings a few memory bells. :`P<br /><br />Did I read your post correctly and you're going to be discussing this with Gary Taubes over the phone?LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-29119922568729686622010-01-19T22:35:06.385+00:002010-01-19T22:35:06.385+00:00Hi LynMarie,
Normally, when a cell burns FAs, the...Hi LynMarie,<br /><br />Normally, when a cell burns FAs, the Acetyl CoA produced stops pyruvate from entering Krebs and the accumulation of pyruvate down-regulates glycolysis.<br /><br />However, taking in lots of FAs depletes glycerol-3-phosphate which up-regulates glycolysis, or to be more specific, the pentose phosphate pathway.<br /><br />Nige.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-25295752174940012772010-01-19T22:20:24.899+00:002010-01-19T22:20:24.899+00:00Hi Nige,
I get what you're saying here and th...Hi Nige,<br /><br />I get what you're saying here and think it's a well thought out theory. I can see a potential point of contention however. Getting glucose inside a fat cell is the first major step in the production of G3P. The second major phase is getting the glucose to go through glycolysis, and an argument can be made that glycolysis doesn't happen much when a lot of fatty acids are being "burned" for energy. As you know I'm sure, during LCHF dieting our bodies switch to a fat-burning mode. I need to refresh my memory regarding how glycolysis and beta-oxidation relate to one another, but I think some product of fatty acid oxidation builds up and inhibits glycolysis. Time to break out the Biochemistry text yet again!LynMarie Dayehttps://www.blogger.com/profile/08486294119556517760noreply@blogger.com