tag:blogger.com,1999:blog-9174025374821038087.post1005470449695907607..comments2024-01-29T17:51:55.608+00:00Comments on Nige's Diet & Nutrition Blog: Fun with maths: How many grams of "X" does it take to achieve "Y" mmol/L of "X" in the blood?Nigel Kinbrumhttp://www.blogger.com/profile/03368973941328529619noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-9174025374821038087.post-20395728739275427822014-09-06T09:30:09.050+01:002014-09-06T09:30:09.050+01:00Never trust anyone! Having become tired of doing s...Never trust anyone! Having become tired of doing so many PubMed searches, I didn't do a search for the effect of large amounts of exogenous ketones on serum insulin level. Go on, you <b>know</b> you want to.<br /><br /><br /><br />Have a good one, yourself!Nigel Kinbrumhttp://nigeepoo.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-65531928924394595222014-09-06T09:25:34.447+01:002014-09-06T09:25:34.447+01:00No, I just trust that you did and there must be no...No, I just trust that you did and there must be none.<br />Now, have a nice day.Vimnoreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-27791203542605515102014-09-06T09:22:00.126+01:002014-09-06T09:22:00.126+01:00I don't know if there are any studies on the e...I don't know if there are any studies on the effect of large amounts of exogenous ketones on serum insulin level. Large amounts of GHB sends people to sleep, despite it being excitatory.<br /><br />I know what happens, from NFB loop theory.<br /><br />Have you had a rummage through PubMed?Nigel Kinbrumhttp://nigeepoo.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-34306979413014824092014-09-06T09:17:01.562+01:002014-09-06T09:17:01.562+01:00I´m also engineer, Nigel, and oscillators -for exa...I´m also engineer, Nigel, and oscillators -for example- were a topic in my classes until recently.<br /><br />Thanks anyway.<br />I´m just looking for some direct measurements on insulin that supports what you're saying.Vimnoreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-89020997300751348172014-09-06T09:13:05.550+01:002014-09-06T09:13:05.550+01:00I just corrected the link in my above post, in cas...I just corrected the link in my above post, in case you clicked on the old one. The new link shows the schematic for a NFB loop.Nigel Kinbrumhttp://nigeepoo.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-51141341867852650242014-09-06T09:10:09.654+01:002014-09-06T09:10:09.654+01:00Thanks anyway Nigel.Thanks anyway Nigel.Vimnoreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-86604089833611892572014-09-06T09:05:50.273+01:002014-09-06T09:05:50.273+01:00Some things just don't have references. You...Some things just don't have references. You're going to have to take my word as an Engineer on this.<br /><br />See http://nigeepoo.blogspot.co.uk/2014/08/negative-feedback-loops-tolerance.html<br /><br />If exogenous ketones raise serum ketones to >6mmol/L, this forces the loop to run open, which results in a <b>large</b> increase in insulin level, as the output of the loop (insulin) hits its positive end-stop.Nigel Kinbrumhttp://nigeepoo.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-53867310710667099272014-09-06T08:56:07.232+01:002014-09-06T08:56:07.232+01:00Thanks Nigel, but can you elaborate better that &q...Thanks Nigel, but can you elaborate better that "exogenous ketones are a different matter entirely"? Any references?Vimnoreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-7073302324505152962014-09-06T08:51:04.951+01:002014-09-06T08:51:04.951+01:00That's because they're endogenous ketones ...That's because they're endogenous ketones produced by starvation. It takes only a tiny increase in endogenous insulin production to stop endogenous ketone production from increasing any further, so you can't see it on the above graph.<br /><br />Exogenous ketones are a different matter entirely, as they force the NFB loop to run open-loop.Nigel Kinbrumhttp://nigeepoo.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-9174025374821038087.post-87308247889962399852014-09-06T08:35:20.173+01:002014-09-06T08:35:20.173+01:00I don´t see any insulin response in the graph you ...I don´t see any insulin response in the graph you show along with raising ketones.Vimnoreply@blogger.com