|From Calcium Signaling and Exocytosis in Adrenal Chromaffin Cells Well, it's got something to do with calcium!|
From Aging and calcium as an environmental factor.
"The consequences of calcium deficiency might thus include not only osteoporosis, but also arteriosclerosis and hypertension due to the increase of calcium in the vascular wall, amyotrophic lateral sclerosis and senile dementia due to calcium deposition in the central nervous system, and a decrease in cellular function, because of blunting of the difference in extracellular-intracellular calcium, leading to diabetes mellitus, immune deficiency and others.
I highlighted ALS in red, as many Facebook friends have been having buckets of water & ice cubes tipped over themselves to raise money for research into this fatal condition.
So, what prevents & reverses migration of calcium from hard tissues to soft tissues?
Clue: It carboxylates osteocalcin in bone matrix Gla proteins. Yes, it's Vitamin K2.
See also Calcium, parathyroids and aging.