Polite requests, Part 2.

Having had a polite request from someone with T2DM, I hereby disengage from trading insults.

Time to disengage.

Sometimes, when a lot of mud gets flung, some of it can stick to the wrong people.

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

Serendipity strikes again!

The tipping point and the metabolic syndrome.

The picture that I used for the last post came from Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

Fascinating stuff!

Metabolic flexibility - do you have it?

I'm not quite sure what the picture below means (I need to do a spot of reading!).

Metabolic flexibility "bowl" and "Adaptability envelope"

While replying to Kade Storm this morning, it suddenly occurred to me that the Eskimos have an unusual ability. RER (a.k.a. RQ) normally varies from 0.7 (100% fat-burning) to 1.0 (100% carb-burning aerobically) to >1.0 (100% carb-burning, some anaerobically). Eskimos manage to get an RER of 0.600 *Mind blown.*

One theory that comes to mind is BAT. As Eskimos live in a very cold environment, it's possible that this has resulted in them having a large amount of BAT. BAT is very metabolically-active and turns ATP into heat via UCPs.

Nowadays, first-world people don't live in a cold environment (unless they're old and/or poor), so we don't have much BAT after infancy. Naturally-skinny people may be that way due to having more BAT. They seem to be able to eat whatever and as much as they want without getting fat. I'd like to scratch their eyes out! ;-)

Not exactly rocket science, is it? Part 2

If there is a deficiency in "X", taking supplement "X" will correct the deficiency in "X".
∴ If problem "Y" is caused by a deficiency in "X", taking supplement "X" will fix problem "Y".

If there's no deficiency in "X", taking supplement "X" won't make any difference.
∴ If problem "Y" isn't caused by a deficiency in "X", taking supplement "X" won't fix problem "Y".

If a person spends a lot of time outdoors in skimpy clothing in sun that's higher than 45deg in the sky, it's highly likely that they won't be deficient in Vitamin D3. Therefore, supplementing with 5,000iu/day of Vitamin D3 won't highly likely do anything.

∴ If the above sun-worshipping person has type 2 diabetes, supplementing with 5,000iu/day of Vitamin D3 won't highly likely make any difference.

Not exactly...

Rocket Science!

There will be some people for whom all of the supplements & exercises that I recommend don't make any difference to their type 2 diabetes. Sorry about that. A low-carb (but not very-low-carb) diet will minimise your serum glucose level fluctuations without increasing your serum NEFA level excessively. See The problem with Diabetes.

I'm Disqus'ted!

It's been 4 days and my Comments Import Status progress is still 0.0%.

It's so unfair!

Yes, I'm trying to migrate my comments over to Disqus. It works well at
http://carbsanity.blogspot.co.uk/. I can see who's replied to my comments and I can also edit my comments.

Can supplements & exercise cure Type 2 diabetes?

Definitely, maybe!

From http://health-in-hand.co.uk/2013/03/24/supplements-for-the-non-supplement-takers/

According to Hyppönen and Power, in a large sample of the white British population born in 1958, 60.9% of subjects had serum 25(OH)D (the active metabolite of Vitamin D) of less than 75nmol/L in Summer & Autumn, and 87.1% had serum 25(OH)D of less than 75nmol/L in Winter & Spring. 75nmol/L ≡ 30ng/mL.

 From Hypovitaminosis D is associated with insulin resistance and β cell dysfunction, 2-hour post-load blood glucose level in an oral glucose tolerance test (OGTT) has a negative correlation with 25(OH)D concentration (Fig 1C). 25(OH)D concentration has a positive correlation with insulin sensitivity (Fig 2A). Therefore, 2-hour post-load blood glucose level in a OGTT has a negative correlation with insulin sensitivity.

"Extrapolation from the observations in the current study suggests that increasing 25(OH)D from 10 to 30 ng/mL can improve insulin sensitivity by 60%, from 3.8128 to 6.1176 (umol/L)·m-2·min-1·(pmol/L)-1. This improvement in insulin resistance could potentially eliminate the burden on cells and reverse abnormal glucose tolerance. Furthermore, the 60% improvement in insulin sensitivity that results from vitamin D treatment indicates that that treatment is more potent than either troglitazone or metformin treatment (54% and 13% improvement in insulin sensitivity, respectively). The modest effect of vitamin D on insulin sensitivity in individual persons may translate into a dramatic effect in the population as a whole because of the high prevalence of hypovitaminosis D, which, in a large population, carries an attributable risk for type 2 diabetes and the metabolic syndrome. Although a review of the literature suggests non-calcium-mediated effects, the underlying molecular mechanism remains to be elucidated."

As my 2-hour post-load blood glucose level in a OGTT became low (3.7mmol/L, from 8.7mmol/L in 2003) after supplementing with 5,000iu/day of Vitamin D3, this means that my insulin sensitivity became high. Therefore, I cured my pre-type 2 diabetes using supplements.

My fasting blood glucose level also fell from 6.8 mmol/L (> 7.0mmol/L = type 2 diabetes diagnosis) to 5.0mmol/L. I achieved this without taking any drugs for type 2 diabetes - not even Metformin, which I consider to be a safe & effective insulin-sensitiser, though it can cause gastric distress and B12 absorption issues, long-term. The supplements that I took had zero side-effects and merely corrected deficiencies.

Diabetes drugs cannot cure type 2 diabetes. However, supplements & exercise can cure type 2 diabetes, if the type 2 diabetes is caused by nutrient deficiencies and/or sedentary behaviour and if all pancreatic beta cells haven't been destroyed. Insulin injections can preserve pancreatic beta cells, while insulin resistance is being tackled. See Dr. Richard K Bernstein on insulin for type 2 diabetics, and some definitions.

Sadly, if there are no nutrient deficiencies and/or all pancreatic beta cells have been destroyed, supplements & exercise will not help.

Ketogenic diets - when they're not ketogenic.

High in the Arctic, Eskimo!

It's generally assumed that eating less than 50g/day of carbohydrate results in ketosis. Assume makes an ass out of "u" and "me". From Lyle McDonald's book The Ketogenic Diet:-

The Ketogenic Ratio (KR) = K/AK, where K = Ketogenic stuff and AK = Anti-ketogenic stuff.

K/AK =  (0.9*Fat + 0.46*Protein)/(1.0*Carbohydrate + 0.1*Fat + 0.58*Protein) where Fat, Protein & Carbohydrate are in grams.

For the treatment of epilepsy (very strongly ketogenic), K/AK must be greater than 1.5. For people who want to get into benign dietary ketosis, K/AK can be lower.

Eskimos eat a diet containing virtually zero dietary carbohydrate (~50g/day as muscle & liver glycogen). However, they are not in ketosis. See STUDIES ON THE METABOLISM OF ESKIMOS.

Eskimos eat so much protein that the Anti-ketogenic effect of Protein offsets the Ketogenic effect of Fat + Protein. Table IV is interesting, as it shows how much energy is lost as ketones on the third day of successive fasts in non-Eskimos (Subject #1 fasted once only). Note:- Beta-hydroxybutyric acid  produces 5kcals/g.

Subject #1:- 10.5kcals. ?kcals, ?kcals.
Subject #2:- 100.5kcals, 7.0kcals, 2.75kcals.
Subject #3:-  9.75kcals, 0.0kcals, 0.0kcals.

The answer is "not a lot" (except for Subject #2 on the first fast).

Continued on Ketogenic diets - when they're not ketogenic, Part 2.

New treatment might put Type 2 diabetes in remission.

From:
http://www.ctvnews.ca/mobile/new-treatment-might-put-type-2-diabetes-in-remission-1.806064
"A new study by Toronto researchers on a new way to treat type 2 diabetes shows it may cause temporary remission of the disease in up to 75 per cent of patients.
 
The new treatment involves taking four shots of insulin -- the medication required by some diabetics to control blood sugar levels -- per day for just one month. This is a change from the usual treatment, which involves daily insulin shots over an extended period of time.

Patients develop diabetes when their pancreas can't produce enough insulin to lower blood sugar levels after meals. While medications can temporarily boost insulin production, many type 2 diabetics face a lifetime of daily insulin shots. Over time, patients with the disease can go on to suffer from a range of complications including blindness, heart disease, kidney problems and nerve damage.

Dr. Bernard Zinman, the director of the Leadership Sinai Centre for Diabetes and lead researcher of the study, explained how the new treatment works to CTV News. According to Zinman, by giving type 2 diabetics concentrated levels of insulin for a month early on in their disease, their pancreas, in effect, gets a "a break."

"The diabetes in essence goes away because their own pancreas now can make enough insulin," he said.

After the month on concentrated doses, patients are required to take another type of medication to "maintain" the remission, said Zinman.

Zinman said that the period of remission may eventually wear off, and so he sees the possibility of a future "top-up" treatment, which would last another month.

While the remission period can vary in patients, the prospect of improving pancreatic function is an exciting development in diabetes research, said Dr. Ravi Retnakaran, co-researcher of the study.

"This is a very novel and exiting way of treating diabetes that could have important implications," said Retnakaran.

For patients involved in the study, the treatment has had a major impact on their quality of life. Francoise Hebert was diagnosed with type 2 diabetes in November 2010. Seven months ago she enrolled in the study, and while she found the four daily insulin doses challenging, her blood sugar levels are now normal.

Hebert now happily tells people she "no longer has the disease," and enjoys knowing she's delayed any progression of diabetes-related complications.

"It feels fabulous," she said with a laugh. "It feels absolutely wonderful."

In addition to having her diabetes go into remission, Hebert says she's also learned how to eat better and hopes to eventually be able to get her weight under control.

Type 2 diabetes is primarily caused by an unhealthy diet and physical inactivity.

The research team at Mount Sinai Hospital hopes to have study results in a year or two, as well as more safety data on the medication."

What the world eats -- a week's worth of groceries.

I saw http://imgur.com/a/mN8Zs on Twitter. EDIT: Now on http://imgur.com/gallery/LvCgp

Britain

USA

Chad

Hmmm. Have you spotted the "elephant in the room"?

My missions.

I was once asked:- "That is my cause, that is my mission, what is your cause Nigel ? What is your mission ?"

My reply was "Anyway, my mission is to disseminate (hopefully accurate) information about Diet, Nutrition, Fitness & Random stuff in a way that’s interesting to the lay public – hence the videos and pictures."

Information. We want information...

I am not a number. I am a free man!

My primary mission is, as stated above, to provide free information of high quality in a form that you can easily understand and to support that information with high quality evidence.

I believe that you don't want to read too much techy stuff, no matter how fascinating it may be to me!

My secondary mission is to expose misinformation. I am like The Terminator. I vill not stop. Eva!

Hasta la vista, baby!

Diogenes: High protein + low GI = Weight-loss maintenance WIN.

See Diets with High or Low Protein Content and Glycemic Index for Weight-Loss Maintenance.

LP = Low Protein. HP = High Protein. LGI = Low GI. HGI = High GI.

"In conclusion, in this large, randomized study, a diet that was moderately high in protein content and slightly reduced in glycemic index improved the rate of completion of the intervention and maintenance of weight loss and therefore appears to be ideal for the prevention of weight regain."

Note that Low GI isn't the same as Low carb. The Low GI diets had ~43% of total energy from carbohydrate. The Low GI diets were not Low carb diets. They weren't as High carb as Healthy Eating Guidelines (55% of total energy from carbohydrate).

The most simple tip to lose weight EVER is “Eat less and move more”.

Said Gaz at Cycle Of Life - Fix You.
He went from this...

Not a happy bunny.

To this...

A happy bunny.

Now tell me that ELMM doesn't work!

Hypoglycaemic counter-regulation at normal blood glucose concentrations in patients with well controlled type-2 diabetes.

Hat tip to Graham of the Lowcarb Team. See Hypoglycaemic counter-regulation at normal blood glucose concentrations in patients with well controlled type-2 diabetes.

"Background

Intensive treatment to achieve good glycaemic control in diabetic patients is limited by a high frequency of hypoglycaemia. The glucose concentrations at which symptoms and release of counter-regulatory hormones takes place have not been studied in patients with well controlled type-2 diabetes.

Methods

We studied seven well controlled, non-insulin treated, type-2 diabetic patients (mean HbA1 [corrected according to Diabetes Control and Complications Trial] 7·4%, SD 1·0) and seven healthy controls matched for age, sex, and body mass index with a stepped hyperinsulinaemic hypoglycaemic glucose clamp. Symptoms, cognitive function, and counter-regulatory hormone concentrations were measured at each glucose plateau, and the glucose value at which there was a significant change from baseline was calculated.

Findings

Symptom response took place at higher whole-blood glucose concentrations in diabetic patients than in controls. Counter-regulatory release of epinephrine, norepinephrine, growth hormone, and cortisol showed a similar pattern—eg, at blood glucose concentrations of 3·8 mmol/L [SD 0·4] vs 2·6 [0·3] for epinephrine.

Interpretation

Glucose thresholds for counter-regulatory hormone secretion are altered in well controlled type-2 diabetic patients, so that both symptoms and counter-regulatory hormone release can take place at normal glucose values. This effect might protect type-2 diabetic patients against episodes of profound hypoglycaemia and make the achievement of normoglycaemia more challenging in clinical practice."

What the above study shows is that, in people with "well controlled" T2DM (mean HbA1c 7·4%, SD 1·0 is poor control. Less than 6% is good control), there is counter-regulatory release of adrenaline, noradrenaline, growth hormone and cortisol at normal blood glucose levels. This is bad, as it's unhealthy to have release of counter-regulatory hormones under normal living conditions.

EDIT: Graham posted this study in support of his belief that there is low/no cortisol etc secretion due to blood glucose not falling low enough. This study actually counters his belief, as blood glucose doesn't fall low enough due to excessive cortisol etc secretion!

Music AND lights.

What else but...

Not only can I now tolerate loud music but also I can now tolerate bright lights. Misaligned car headlamps no longer annoy me like they used to.

Can very-low-carb diets impair your mental faculties?

I wanna tell you a story...

In 2006, I had a test done on my pituitary gland*, called an Insulin Shock Test. It was pretty much what it said on the tin. I laid on a hospital bed, I was injected with an overdose of insulin and I was monitored for blood glucose and growth hormone levels every 30 minutes.

My blood glucose fell and fell and fell and fell until it reached ~1.5mmol/L (~27mg/dL). What happened was interesting. I came out in a cold sweat and developed a tremor. Apart from that, I felt fine. The consultant in charge was chatting to me and I was chatting to him. Eventually, I was given a sandwich, a yoghurt and a banana to eat.

Some time later, when I had stopped sweating and shaking, the consultant returned and told me that I had become confused. My brain had ceased to function correctly due to a lack of blood glucose (the insulin had totally suppressed serum FFAs and ketones, so there were no other brain fuels available), but I was too mentally-impaired to know that I was mentally-impaired. As far as I was concerned, everything was fine & dandy. This is like the Dunning-Kruger effect.

Referring to Blood Glucose, Insulin & Diabetes, as blood glucose falls due to either starvation or a lack of dietary carbohydrate, insulin falls and glucagon rises, stimulating the liver to convert liver glycogen into glucose for export to the blood. Eventually, liver glycogen becomes depleted and blood glucose falls again. The pituitary gland notices this and secretes AdrenoCorticoTropic Hormone (ACTH) which stimulates the adrenal cortex to secrete cortisol. The adrenal glands are also stimulated to secrete adrenaline (a.k.a. epinephrine). Cortisol increases the conversion of amino acids and other substrates into glucose by the liver and kidneys. If blood glucose continues to fall, the pituitary gland secretes growth hormone (GH), which has an anti-insulin effect.

From http://anthonycolpo.com/boosting-growth-hormone-with-diet-training-fact-or-fiction-part-2/:-
"after the zero-carb phase, subjects reported symptoms of hypoglycemia that included weakness, irritability, mental confusion, nausea, hunger, cold sweating and disturbed co-ordination. GH levels were higher during exercise after the low-carb phase, but so too were levels of other fuel mobilizing hormones such as epinephrine, glucagon, and cortisol." Epinephrine, glucagon, and cortisol are stress hormones. Chronically-high blood levels of stress hormones disrupt sleep and cause irritable, aggressive behaviour.

Ethanol inhibits gluconeogenesis in the liver (possibly also in the kidneys) resulting in worse hypoglycaemia. Worse hypoglycaemia results in more ACTH & adrenaline secretion and worse hypercortisolaemia, which can adversely affect the hippocampus, impairing memory.

In conclusion, if you want to eat a very-low-carb diet, long-term:-1) Don't do much high-intensity exercise. See "Funny turns": What they aren't and what they might be.
2) Don't drink much (if any) booze.

*My pituitary gland failed the test by secreting only 40% the amount of GH that it was supposed to. For six months, I was given GH to inject using a special pen with a 8mm x 0.3mm needle. By the end of the six month trial, I had perfected the art of painless injection. The trial was discontinued due to lack of any noticeable benefit (17 days supply of GH @0.3mg/day cost £120!).

Full script of mum's funeral.

http://homepage.ntlworld.com/nigel.kinbrum/Laurel%20Carey%20-%20family%20script.htm

All blue underlined text are clickable links.

Type 2 diabetes in the UK.

From Insulin usage in type 2 diabetes mellitus patients in UK clinical practice: a retrospective cohort-based analysis using the THIN database:-

"Importantly, this analysis has been conducted using routine data from UK clinical practice, which allows an insight into how patients are managed in current UK practice. In summary, this study demonstrates a persisting delay both in oral therapy escalation and insulin initiations in patients with type 2 diabetes, with a relative reduction in the effectiveness of oral therapy escalation. There is an apparent threshold HbA1C of > 8.5% beyond which additional oral therapy in routine practice appears unlikely to achieve an HbA1C target ≤ 7.0%.
This study thus highlights the need for more timely escalation of glucose-lowering therapy, including insulin initiation, in order to limit unnecessary patient exposure to hyperglycaemia and associated serious consequences, such as macro-vascular and micro-vascular complications."

An HbA1C of 7.0% still results in macro-vascular and micro-vascular complications. If someone develops type 2 diabetes in the UK, the NHS isn't going to save them. They have to save themselves.

See also Having Diabetes and Car Insurance and Applying for a Driving Licence and Informing the DVLA. Basically, developing type 2 diabetes in the UK sucks.

People who have Impaired Glucose Tolerance need to take action to prevent their condition from deteriorating into full-blown Type 2 diabetes. See http://nigeepoo.blogspot.co.uk/search/label/Diabetes.

Low-glycaemic diet seen to reverse diastolic dysfunction of diabetes.

From http://www.medscape.com/viewarticle/802947?nlid=30763_1301&src=wnl_edit_dail (Medscape log-in required):-

"Of 32 overweight or obese diabetic patients (mean body-mass index, 34) without cardiac disease who were engaged in a "rehabilitation program in order to lose weight" that included two hours of supervised aerobic exercise per day, half followed a low-glycemic diet (25% carbohydrate, 45% fat, 30% protein) and the other half a low-fat diet (55% carbohydrate, 25% fat, and 20% protein) for three weeks. The diets provided the same amount of calories. Those on the low-fat diet then switched to the low-glycemic diet for an additional two weeks"

"....the two diets led to about the same declines in weight and waist circumference..."

The diet was 25% carbohydrate, 45% fat, 30% protein.
It was a low-carbohydrate/low-glycaemic load diet.
It was not a very-low-carb diet.

Weird filters, Part 2.

Here's that weird picture again.

Why is it that some people see the world through weird cognitive bias filters? It makes discussion with them impossible, as what I write is remixed with weird filters into something completely different. They then argue against something completely different, not what I wrote. This is the classic Straw Man argument.

Here are some more examples of remixing with weird filters:-

"I can eat whatever I want" is remixed into "I can eat as much as I want". I actually meant "there are no banned foods".

"Inject some insulin" is remixed into "Shoot-up insulin to cover the 400g of carbs that I never even mentioned!"

To all intents & purposes, I had T2DM. Another 0.2mmol/L on my fasting serum glucose and I would have been diagnosed as having T2DM. As my fasting serum glucose was slowly increasing, it would have soon gone over 7.0mmol/L, had I not got lucky and fixed the underlying problem.

In January 2003, I had impaired Glucose Tolerance (fasting serum glucose = 6.8mmol/L on one OGTT, and 2 hours post-75g glucose load serum glucose = 8.7mmol/L on another OGTT). A sandwich used to send me to sleep.

By September 2008, I had normal Glucose Tolerance (fasting serum glucose = 5.0mmol/L & 2 hours post-75g glucose load serum glucose = 3.7mmol/L on the same OGTT). I also no longer suffered from hyperinsulinaemic drowsiness. I was approximately the same weight that I was in 2003, so the improvement was not due to weight loss.

P.S. Information about ways to tackle Insulin Resistance can be found in Insulin Resistance: Solutions to problems.

N.B. If someone has a valid medical reason for being on a very-low-carb or ketogenic diet, that's fine by me. I don't think that it's necessary for people with T2DM to be on a very-low-carb or ketogenic diet. In fact, eating more carbohydrate allowed Jason Sandeman to reduce his insulin dose for good BG control.

Dr. Richard K Bernstein on insulin for type 2 diabetics, and some definitions.

Dr. Richard K Bernstein:-

Dr. Richard Bernstein, the world's leading low-carb diabetologist, says in Diabetes: The Basics:-
"Many people (including the parents of diabetic children) view having to use insulin as a last straw, a final admission that they are (or their child is) a diabetic and seriously ill. Therefore they will try anything else - including things that will burn out their remaining beta cells - before using insulin. Many people in our culture have the notion that you cannot be well if you are using medication. This is nonsense, but some patients are so convinced that they must do things the “natural” way that I practically have to beg them to use insulin, which is as “natural” as one can go. In reality, nothing could be more natural. Diabetics who still have beta cell function left may well be carrying their own cure around with them - provided they don’t burn it out with high blood sugars and the refusal to use insulin."

Some definitions:-

From Low-carbohydrate diet:-
"The term "low-carbohydrate diet" is generally applied to diets that restrict carbohydrates to less than 20% of caloric intake, but can also refer to diets that simply restrict or limit carbohydrates."
A typical woman consumes ~2000kcals/day. A typical man consumes ~2,500kcals/day. Therefore...

Very-low-carb diet = <10% energy from carbs ≡ <~50 or ~62.5g carbs/day.
Low-carb diet = <20% energy from carbs ≡ <~100 or ~125g carbs/day.
"Healthy eating" = >55% energy from carbs ≡ >~275 or ~344g carbs/day.

Of roads and rulers.

In the UK, unadopted roads can be well-maintained, or look like this...

Residents of Tennyson Avenue, Thorne, have been battling for years to have their unadopted road repaired. They have now been told that they need to pay £5,300 each for the road to be resurfaced. Pictured back l-r are Russ Clarke, Sue Taylor, Anne Kershaw, and her husband George. Front l-r are Lyn Shadlock, and Paul Willerton. Picture: Liz Mockler D2524LM

The following scenario is made-up. All characters are fictitious and any similarity to anyone living or dead is purely coincidental.

Nigel/Nigella lives on an unadopted road and got fed up riding his/her bicycle on the road as it was full of pot-holes. He/she called a residents meeting and made the following proposal:-

I will organise the repair of our road. I will phone some road repair companies and get them to quote for the repair of our road. I will call another residents meeting to tell you the pros and cons of each company and their quotes. We will then vote to decide which company gets the job. We will all contribute an equal amount to cover the cost of the repair plus a reasonable allowance for me, to cover my time spent.

Two outcomes come to mind.

1) Nigel/Nigella is a charismatic "people-person". All of the residents agree that Nigel/Nigella can organise the repair of the road and on his/her allowance. They later vote for a repairer and pay Nigel/Nigella the monies required. Nigel/Nigella gets the company to repair the road. Everyone is deliriously happy. Nigel/Nigella becomes head of the residents association. Nigel/Nigella becomes Mayor. Nigel/Nigella becomes MP. Nigel/Nigella becomes Prime Minister.

2) Nigel/Nigella is a nerd with poor social skills. One or more of the residents refuses to pay for repair of the road as they drive "Chelsea Tractors" (4x4s) and potholes are not a problem for them. The project is cancelled. Nigel/Nigella vows to not bother trying to make life better for people in future. The road remains full of pot-holes, like the one in the picture above.

The above scenario applies to residential roads. Who maintains non-residential roads? If no-one is in charge, all non-residential roads would need toll-barriers at entrances and exits, to collect monies for their maintenance. Alternatively, everyone pays road/council tax to some authority to cover the cost of road maintenance plus other essential services plus cost of organisation and lets the authority get on with it. "Top-down" authority has its advantages. We pay someone else to sweat the petty stuff.

Many years ago, life was simple. Things got done by individuals and groups of individuals. Nowadays, life is extremely complicated. To make things run relatively smoothly, we have laws, rules & regulations. Some laws, rules & regulations are good and some are stupid. The only way to get rid of the stupid ones is to vote for the person who pledges to abolish the largest number of stupid ones (and introduce the smallest number of new stupid ones) and hope that that person sticks to their pledges if they are elected.

Be afraid. Be very afraid.

Be thankful that we Brits aren't allowed to bear arms, as this would totally happen if we were...

There, their, they're! I think that that's enough silliness for one day.

Expectations, Surprises and Internet eejits.

Expectations:

In mid-July 2007, I noticed that mum was slightly confused. By the beginning of August 2007, mum had become noticeably confused (she locked herself out of her bungalow and two days later, didn't recognise her own living room). I did some research on the internet. As mum already had Parkinson's Disease for a few years, the most likely diagnosis for her increasing confusion was Dementia with Lewy Bodies (DLB). According to the DLB site, the mean survival time was six years from the first onset of symptoms. So, for the last five years and nine months, I've known roughly what was going to happen, how it was going to happen and how & when it was going to end. Sometimes, ignorance is bliss.

Surprises:

Life can be stranger than fiction. When mum divorced dad forty-five years ago, mum got the house as my sister & I were living there and she got child maintenance payments from dad. As a result, dad had nothing to do with mum & me from that day onwards. He still maintained contact with my sister.

Yesterday, while sitting in a solicitor's office, my mobile phone rang. It was my sister. She had tried to phone dad on Monday to inform him of mum's death, but he wasn't answering the phone. She phoned one of dad's family to get them to check on him. He had a fatal heart attack on the same day that mum died. Spooky!

Internet eejits:

1) I received the following email at 04:08 today:-
"Dear Nigeepoo,

Your account on BodyRecomposition Support Forums has been locked because someone has tried to log into the account with the wrong password more than 5 times. You will be able to attempt to log in again in another 15 minutes.

The person trying to log into your account had the following IP address: 96.47.226.20

Don't forget that the password is case sensitive. Forgotten your password? Use the link below:
http://forums.lylemcdonald.com//login.php?do=lostpw

All the best,
BodyRecomposition Support Forums"
You'll never guess my password.

2) Read THIS (everything turned out O.K. in the end!)

3) Read THIS (warning, very strong language!).

I show no mercy to internet eejits. You have been warned!

EDIT: Alan Aragon fully supports Evelyn Kocur (CarbSane). Therefore, anyone who attacks Evelyn must also attack Alan, otherwise they are a hypocrite. Good luck with that!

Quality >> Quantity.

Mum passed away peacefully in the middle of the night. I'm waiting for paperwork to be done.

"And the best you can hope for is to die in your sleep."

On the internet, I read that Dementia with Lewy bodies has a mean survival time of 6 years from the onset of symptoms. Mum first became confused in mid-July 2007, so it's been just under 6 years. Does this mean that all of the supplements I gave her were worthless. Hell, no!

As mentioned in Look after your brain., mum's MMSE score increased from 14 to 26 out of 30 after taking medication and supplements. The medication gave a 3 point increase in MMSE score on average, so the rest of the increase in MMSE score was probably due to the supplements, which had no undesirable side-effects.

On Christmas day 2008, mum was capable of preparing Brussels sprouts for cooking, though she got the knives, forks & spoons mixed up when she tried to lay the table. Here's her final Christmas at home. Roast duck with all of the trimmings. Om, nom, nom!

Mum's last Christmas at home.

People commented on how happy mum always was. Even though she probably didn't know who she was or I was, when I said "Fancy a cup of tea, mum?", she'd reply "Ooh yes, please!" That was the last part of her speech to go.

In conclusion, I believe that quality of life trumps quantity of life, so supplementation for the win.

Politics, Religion and Diet.

Three subjects that people love to argue about, as they are about beliefs ;-)

Human population vs Year.

 

Politics:

In Palaeolithic times, there weren't many people living on this planet. People hunted and gathered their food, and had relatively non-hierarchical, egalitarian social structures. According to archaeologists, violence in hunter-gatherer societies was ubiquitous. Approximately 25% to 30% of adult male deaths in these societies were due to homicide, compared to an upper estimate of 3% of all deaths in the 20th century. The cause of this is near constant tribal warfare: "From the !Kung in the Kalahari to the Inuit in the Arctic and the aborigines in Australia, two-thirds of modern hunter-gatherers are in a state of almost constant tribal warfare, and nearly 90% go to war at least once a year." However, due to the extremely low population back then, extremely few people were killed in absolute terms. Then, around 10,000 BC, some bright spark/bulb invented agriculture...

Fast-forward a few thousand years to the time of Genghis Khan. He came to power by uniting many of the nomadic tribes of north-east Asia. The Mongol invasions resulted in wholesale massacres of civilian populations. His descendants went on to stretch the Mongol Empire across most of Eurasia by conquering or creating vassal states out of all of modern-day China, Korea, the Caucasus, Central Asian countries, and substantial portions of modern Eastern Europe, Russia and the Middle East. Many of these invasions repeated the earlier large-scale slaughters of local populations. However, due to the low population (around 300 million), few people were killed in absolute terms. Then, around 1,600 AD, some bright spark/bulb invented government...

As mentioned in How did we get to where we are today? Part 2., the invention of liberal government encouraged the exchange of ideas and entrepreneurship. Monarchies taxed people, but their bureaucracies stifled entrepreneurship, so the French and the Chinese invented loads of stuff that never saw the light of day. We Brits got lucky. As a result, the Industrial Revolution created wealth out of dirt, which led to rapid economic growth and rapid population growth. The Green Revolution led to more rapid population growth.

Fast-forward to the 21st Century. Warfare has killed millions of people. Rulers have killed hundreds of millions of people (the vast majority by totalitarian & authoritarian regimes), according to Anarchy Begins at Home: The Blog Series Part 6 – Democide. However, due to the extremely high population, only approximately 5.6% of the total population have been killed by rulers. That's what I call relative peace.

EDIT: I don't want a system where entire populations can be slaughtered by armies led by a charismatic leader. I also don't want a system where the poor & underprivileged are "free" to die in poverty. Some people scrounge off Social Security, but the amount of money scrounged by them pales into insignificance compared to the amount of money scrounged off the rest of us by the wealthiest people on this planet.

 

Religion:

I'm not religious. I have no problem with people believing in God, as long as they have no problem with me not believing in God. A thought experiment that you may find interesting is God's Debris, by Scott Adams.

 

Diet:

Read the rest of my blog, dammit!

In other news...
Mum is now in a coma, but her breathing is regular.

Failure to communicate, civil wars and dim bulbs.

Hat-tip to marie (who's a very bright bulb indeed!) for the following video.


Whaz so civil 'bout war anyway?

The reason why I'm writing this is because there's (un)civil war on the internets between various "camps".

At any given moment:-
There are people who function physically & mentally at their best on VLC/Keto diets.
There are people who function physically & mentally at their best on LC diets.
There are people who function physically & mentally at their best on MC diets.
There are people who function physically & mentally at their best on HC diets.
There are people who function physically & mentally at their best on VHC diets.
As people's circumstances change, they move to a different category.

If you don't understand what I wrote above, you are a dim bulb.
If you think that insults can offend me, you are a dim bulb.
If you think that agreeing 90% with someone makes me an ass/arse-kisser, you are a dim bulb.
If you think that I'll take insults from you without retaliation, you are a dim bulb.
Sadly, due to the Dunning–Kruger effect, dim bulbs are too dim to know that they are dim bulbs!
If you are offended by anything that I wrote above, I don't care.

In other news...
Mum's condition has deteriorated to the point where she is unresponsive and no longer has a swallow reflex. It's just a matter of time before she dies. I've been prepared for this for quite some time.

Global Wealth Inequality - What you never knew you never knew.

Hat-tip to Johann Hari for the following video.


Wow, just wow.

How to lose body-fat healthily, Part 2.

Cont'd from How to lose body-fat healthily.

Remember the spoof video below?


I think that I've made it pretty damned clear in this blog that conscious Eat Less, Move More (ELMM) often fails, if the food eaten doesn't suit the person. There's also a brouhaha brewing over what the Paleo Diet is, as there's no one Paleo Diet. So, here's my suggestion for a "Healthy Eating" pamphlet.

Side 1: Base your diet on minimally-refined animal & vegetable produce. Manufactured food products can be eaten as occasional treats.

Side 2: If eating "X" makes you feel unwell, stop eating "X". If eating "X" makes you feel drowsy followed by hunger, you probably have Insulin Resistance.

See Insulin Resistance: Solutions to problems. for ways to reverse Insulin Resistance.