At first glance, Fig 7A looks like a CIH believer's dream come true (apart from the words "High Fat Diet").
Obesity is caused by too much insulin. Game, Set and Match to insulin.
Not so fast! Let's take a look at the rest of Fig 7.
↑ Peripheral Hyperinsulinemia → ↓ Uncoupling Proteins (WAT) → ↓ Energy Expenditure → ↑ Obesity.
Obesity is caused by a reduction in energy expenditure in these mice. Game, Set and Match to The Energy Balance Equation. It’s the Calories, Stupid. In these mice, energy expenditure is strongly influenced by insulin levels. In humans, not a lot. In humans, insulin can act as a stimulant or a sedative.
I'm not an insulin denier as is obvious from my other blog posts. I'm still restricting my carbohydrate intake to ~125g/day from whole foods.
I'm not a food reward denier. I've been using food reward principles to lose weight.
This post will probably annoy some people. Before wasting your time writing a comment, please read my Moderation Policy.